Money FDA approved nasal spray, known as esketamine, to treat major depression is biggest advance in years March 6, 2019March 6, 2019Kelly Tyko, USA TODAYComments Off on FDA approved nasal spray, known as esketamine, to treat major depression is biggest advance in years Spravato nasal spray, also known as esketamine, can now be used to treat depression in adults with treatment-resistant depression.